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目的对有机磷酸农药中毒患者血清总胆汁酸检测的临床意义进行分析和探讨。方法选取2011年6月～2012年12月期间,我院收治的160例有机磷酸农药中毒患者,其中104例为男性,56例为女性;年龄为17～71岁,平均年龄为(48.7±6.8)岁,中毒至就诊时间为1～1.5h,对其临床资料进行了回顾性分析。结果患者血清总胆酸均值为(26.8±5.6)umol/L,远高于正常人群。轻度中毒患者的血清总胆汁酸指标为(14.8±3.9)umol/L,中度中毒患者为(21.8±5.1)umol/L,重度中毒患者为(37.2±7.8)umol/L,其中重度中毒患者的指标显著高于其他两类患者(P<0.05),中度中毒患者的指标显著高于轻度中毒者(P<0.05)。结论有机磷酸农药中毒患者的血清总胆汁酸指标升高程度和中毒程度成正相关,对血清总胆汁酸指标进行检测能够直接反映肝功能的实际状况,对于诊断和评判有机磷酸农药中毒患者实际状况方面具有积极的意义,值得临床推广应用。
Objective To analyze and discuss the clinical significance of detecting serum total bile acid in patients with organophosphate pesticide poisoning. Methods From June 2011 to December 2012, 160 patients with organophosphate pesticide poisoning admitted to our hospital were selected, of whom 104 were male and 56 were female. The mean age was (48.7 ± 6.8) years ) Years old, poisoning to treatment time is 1 ~ 1.5h, the clinical data were retrospectively analyzed. Results The mean serum creatinine was (26.8 ± 5.6) umol / L, much higher than that of normal people. The patients with mild poisoning had a serum total bile acid (14.8 ± 3.9) umol / L, moderate poisoning (21.8 ± 5.1) umol / L and severe poisoning (37.2 ± 7.8) umol / L, The indexes of patients were significantly higher than those of the other two groups (P <0.05). The indexes of moderate poisoning were significantly higher than those of mild poisoning (P <0.05). Conclusions The level of serum total bile acid index in patients with organophosphate pesticide poisoning is positively correlated with the degree of poisoning. The detection of serum total bile acid index can directly reflect the actual status of liver function. For the diagnosis and evaluation of the actual status of patients with organophosphate pesticide poisoning Has a positive meaning, it is worth clinical application.