【摘 要】
：
基因组变异是肿瘤细胞的一个重要特点,其参与肿瘤形成的生物学过程和通路。阵列比较基因组杂交技术能以高分辨率在全基因组范围内检测基因变异和DNA拷贝数改变,尤其能对特异
【机 构】
：
广西医科大学第一附属医院临床医学实验部,复旦大学附属中山医院肝癌研究所,广西医科大学医学检验系,
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基因组变异是肿瘤细胞的一个重要特点,其参与肿瘤形成的生物学过程和通路。阵列比较基因组杂交技术能以高分辨率在全基因组范围内检测基因变异和DNA拷贝数改变,尤其能对特异的基因变异进行高度准确的定位。现综述目前常用的几种阵列平台及其在寻找肿瘤相关基因、监测肿瘤发展进程、判断预后等方面的应用。
Genomic variation is an important feature of tumor cells, which is involved in the biological processes and pathways of tumor formation. The array comparative genomic hybridization technique can detect gene mutations and DNA copy number changes in the whole genome at high resolution, and can specifically locate specific gene mutations with high accuracy. Now review several commonly used array platforms and their applications in the search for tumor-associated genes, monitoring of tumor progression, and prognosis.
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