论文部分内容阅读
儿童上呼吸道A组链球菌的持续存在,使风湿热之发病危险性增大,因此积极治疗以根除上呼吸道链球菌尤为重要。常规应用青霉素治疗后上呼吸道仍隐藏有致病菌,曾有研究分析是由于上呼吸道分泌的β-内酰胺酶抑制了青霉素药效的发挥。故本作者观察了口服青霉素V无效后联用羟氨苄青霉素和克拉维酸钾盐根除上呼吸道A组链球菌之疗效。观察295名儿童,咽拭子培养显示上呼吸道有A组β溶血性链球菌的有131人,占44%,该131名儿童均服用青霉素V,共10日,药物剂量按美国心脏协会控制量服用,3～5天后咽拭子培养结果仍有50名带菌者,其中5名由于未按规定服药而退出实验,余45名儿童年龄平均为7.8岁,检验提示治疗前后
The persistence of Streptococcus group A Streptococcus in children, increasing the risk of rheumatic fever, so active treatment to eradicate upper respiratory streptococcus is particularly important. Routine use of penicillin after treatment of upper respiratory tract is still hidden pathogens, studies have been analyzed is due to the upper respiratory tract secretion of β-lactamase inhibition of penicillin efficacy. Therefore, the author observed the oral administration of penicillin V after the combination of amoxicillin and clavulanic acid potash Eradication of upper respiratory tract group A Streptococcus efficacy. A total of 295 children were enrolled. Throat swabs showed 131 (44%) patients with Group A beta-hemolytic streptococcus in the upper respiratory tract. All of the 131 children received penicillin V for 10 days. The dose of the drug was controlled by the American Heart Association Take 3-5 days later throat swab culture results are still 50 carriers, of which 5 due to failure to take the prescribed medication and quit the experiment, the remaining 45 children aged average of 7.8 years old, before and after test prompts