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苯是一种职业和环境毒物 ,可致人急性骨髓性白血病。苯经细胞色素Ｐ450酶 (Ｃｙｔ Ｐ450 )代谢生成酚 ,随后再进一步代谢为邻苯二酚和氢醌。过去关于ＣＹＰ2Ｅ1与酚代谢的研究较多。本研究采用体外试验方法观察了小鼠肝和肺微粒体中与酚代谢有关的Ｃｙｔ Ｐ450同功酶对其代谢产
Benzene is a kind of occupational and environmental toxicants that can cause acute myeloid leukemia. Benzene is metabolized by the cytochrome P450 enzyme (Cyt P450) to phenol, which is subsequently further metabolized to catechol and hydroquinone. In the past on the CYP2E1 and phenolic metabolism more research. In this study, in vitro experiments were observed in mice liver and lung microsomal phenolic metabolism-related Cyt P450 isozymes their metabolites