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利用链脲菌佐素诱发ＳＤ大鼠糖尿病模型，动态观察其糖性白内障形成过程中不同时期晶体上皮细胞形态学改变，检测糖尿病３０天时晶体上皮细胞ＮａＫＡＴＰ酶活性。结果表明：在大鼠糖性白内障形成中，最早发生改变的是晶体上皮细胞，表现为细胞肿胀，细胞内外出现空泡及内质网池扩张等，白内障出现在晶体上皮细胞改变之后；醛糖还原酶抑制剂ＡＬ１５７６可防止上述改变；白内障形成早期，晶体上皮细胞ＮａＫＡＴＰ酶活性升高。提示晶体上皮细胞的改变在糖性白内障发生中起了关键性的作用。
Streptozotocin-induced diabetic SD rat model of diabetes, dynamic observation of its different stages during the development of glycated cataract crystal epithelial cells morphological changes, 30 days after diabetes mellitus test crystal epithelial cells Na K ATPase activity. The results showed that the earliest changes in the formation of glycocalyx were crystal epithelial cells, which showed cell swelling, vacuoles inside and outside cells and expansion of endoplasmic reticulum, cataract appeared after the change of crystal epithelial cells; aldose Reductase inhibitor AL1576 can prevent the above changes; early cataract formation, crystal epithelial cells Na K ATPase activity increased. Tip changes in the lens epithelial cells in the occurrence of sugar cataract play a key role.