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为进一步探讨浸润性乳腺癌中c myc蛋白的表达及其临床意义 ,为乳腺癌患者的预后和治疗提供某种程度的指导 ,应用免疫组化SP法对 1 1 6例原发浸润性乳腺癌标本进行c myc蛋白表达测定。结果提示 ,c myc蛋白在胞核和胞质中均有表达 ,核染色阳性者 1 3例 ( 1 1 .2 % ) ,与乳腺癌患者预后明显相关 ;细胞质着色者 1 0 8例 ( 93.1 % ) ,中、强阳性表达病例与乳腺癌ER状况呈正相关性。提示c myc蛋白核表达可作为判定乳腺癌预后的重要指标 ,对乳腺癌标本进行c myc表达产物检测可能对治疗有一定的指导意义。
To further investigate the expression of c-myc in invasive breast cancer and its clinical significance, provide some guidance for the prognosis and treatment of patients with breast cancer. Immunohistochemical SP method was used to detect 116 cases of primary invasive breast cancer Specimens were tested for c-myc protein expression. The results showed that c-myc protein was expressed in both nucleus and cytoplasm. Thirteen cases (11.2%) with positive nuclear staining were significantly associated with the prognosis of breast cancer patients. The number of cytoplasmic staining was 108 (93.1% ), The positive expression of strong positive cases and breast cancer ER status was positively correlated. Tip c myc protein nuclear expression can be used as an important indicator to determine the prognosis of breast cancer, breast cancer specimens c myc expression products may have some guiding significance for the treatment.