【摘 要】
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目的 观察海马横切术与立体定向海马杏仁复合体射频热凝术对顽固性颞叶内侧型癫痫患者的治疗效果及其对认知和记忆功能的影响.方法 对12例海马横切术和15例立体定向海马杏仁
【机 构】
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100101北京 安徽医科大学解放军306临床学院,安徽医科大学第五临床医学院;战略支援部队特色医学中心立体定向及脑功能性疾病诊治中心;商洛市中心医院神经内科;战略支援部队特色医学中心立体定向及脑功能
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目的 观察海马横切术与立体定向海马杏仁复合体射频热凝术对顽固性颞叶内侧型癫痫患者的治疗效果及其对认知和记忆功能的影响.方法 对12例海马横切术和15例立体定向海马杏仁复合体射频热凝术的癫痫控制率以及手术前后神经心理学检查(包括韦氏智力检查:言语智商VIQ、操作智商PIQ、总智商FIQ和记忆商MQ)结果进行统计分析.结果 两组患者术后癫痫控制有效率均可达80％以上,海马横切术的无发作率为66.67％,立体定向海马杏仁复合体射频热凝术组为40％,尚未达到明显统计学差异(P＞0.05).两组手术前后神经心理学检查结果均无显著差异(P＞0.05).结论 海马横切术与立体定向海马杏仁复合体射频热凝术治疗顽固性颞叶内侧型癫痫均有效,且对患者认知及记忆等神经功能均无明显损害;海马横切术在癫痫控制方面有明显优势,是一种值得提倡和推广的手术方法,虽然立体定向手术的癫痫发作消失率较低,但并未达到统计学差异,且其微创的特性仍倍受广大颞叶内侧型癫痫患者的青睐.
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