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目的研究蚕蛹油(SilkwormChrysalis,SC)对体内外血栓形成的影响。方法(1)采用动-静脉旁路血栓形成法、电刺激动脉血栓形成法和体外血栓法,观察SC对体内血栓湿重、形成时间以及体外血栓长度和干、湿重的影响。(2)建立血瘀模型,观察SC对血瘀大鼠全血高切、低切粘度的影响。结果(1)SC20.8、31.2mg/kg可显著降低血栓湿重(p<0.05,p<0.01),显著延长血栓形成时间(p<0.01),显著缩短体外血栓长度(p<0.05),并能显著降低体外血栓湿重和干重(p<0.01,p<0.05)。(2)SC20.8、31.2mg/kg可明显降低血液粘度(p<0.01)。结论SC具有抗血栓形成作用,其机制与降低血液粘度改善血液流变性相关。
Objective To study the effect of Silkworm Chrysalis (SC) on thrombosis in vivo and in vitro. Methods (1) Using arteriovenous bypass thrombosis, electro-stimulation arterial thrombosis and extracorporeal thrombosis, observe the effects of SC on thrombus wet weight, formation time, and in vitro thrombus length and dry and wet weight. (2) Blood stasis model was established to observe the effect of SC on high-cut and low-cut viscosity of whole blood of blood stasis rats. Results (1) SC20.8 and 31.2 mg/kg could significantly reduce the thrombus wet weight (p<0.05, p<0.01), significantly prolong the thrombus formation time (p<0.01), and significantly shorten the in vitro thrombus length (p<0.05). And can significantly reduce the in vitro thrombus wet weight and dry weight (p <0.01, p <0.05). (2) SC20.8, 31.2 mg/kg can significantly reduce blood viscosity (p<0.01). Conclusion SC has antithrombotic effects, and its mechanism is related to reducing blood viscosity and improving hemorheology.