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目的:探讨慢性丙型肝炎患者自身抗体的阳性率及临床意义。方法:应用ELISA法检测105例慢性丙型肝炎患者血清中的抗核抗体,用免疫印迹法检测抗肝肾微粒体抗体,选择96例慢性乙型肝炎患者和80例健康人分别作为对照组。结果:105例慢性丙型肝炎患者自身抗体总阳性率为48.6%,显著高于慢性乙肝组(7.3%)和健康对照组(2.5%)。自身抗体阳性组患者的平均年龄(47.3±15.5)大于自身抗体阴性组(38.1±14.9)(P<0.05)。自身抗体阳性组中肝纤维化发生率(68.6%)高于自身抗体阴性组(48.1%)(P<0.05)。但两组间性别构成和HCV RNA阳性率无显著性差异(P>0.05)。结论:血清自身抗体的检测有助于慢性丙型肝炎的诊治和病情评估。
Objective: To investigate the positive rate of autoantibodies in patients with chronic hepatitis C and its clinical significance. Methods: The anti-nuclear antibodies in serum of 105 patients with chronic hepatitis C were detected by ELISA. Anti-hepatocyte microsomal antibody was detected by immunoblotting. 96 patients with chronic hepatitis B and 80 healthy individuals were selected as the control group. Results: The total positive rate of autoantibody in 105 patients with chronic hepatitis C was 48.6%, significantly higher than that in chronic hepatitis B (7.3%) and healthy controls (2.5%). The mean age of patients with positive autoantibodies (47.3 ± 15.5) was greater than that of autoantibodies negative (38.1 ± 14.9) (P <0.05). The incidence of hepatic fibrosis (68.6%) in autoantibody positive group was higher than that in autoantibody negative group (48.1%) (P <0.05). However, there was no significant difference in sex composition and HCV RNA positive rate between the two groups (P> 0.05). Conclusion: The detection of serum autoantibodies is helpful for the diagnosis and treatment of chronic hepatitis C.