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据近年来国内外实验研究和临床证实,眼碱性烧伤后角膜基质及房水中维生素C浓度锐减是发生角膜溃疡的重要原因之一。消化道外及局部补充大剂量维生素C,并综合其他治疗措施,可明显地加速角膜上皮细胞及基质层胶原纤维的修复,是减少眼碱烧伤后角膜溃疡和穿孔等并发症的重要措施之一。一、眼碱性烧伤后角膜溃疡的发生机理 (一)胶原酶溶解胶原纤维胶原纤维是构成角膜支架组织的主要有机成分。眼碱性烧伤后反复发生的无菌性角膜溃疡,是由于角膜烧伤后所产生的胶原酶溶解角膜胶原纤维的结果。角膜溃疡通常发生于眼碱性烧伤2～3周后,这是由于伤后2周末开始,角
In recent years, experimental studies at home and abroad and clinically confirmed that corneal stroma and aqueous humor significantly decreased the concentration of vitamin C is one of the important causes of corneal ulcer. Digestive tract and local supplement of large doses of vitamin C, and combined with other treatment measures, can significantly accelerate the corneal epithelial cells and stromal collagen repair, is to reduce the corneal ulcer and perforation and other complications after corneal alkali burn one of the important measures. First, the pathogenesis of corneal ulcer after ocular alkaline burn (A) Collagenase collagen fibers Collagen fibers constitute the main organic components of corneal scaffold tissue. Aseptic corneal ulcers, which recur after ocular alkaline burn, are the result of collagenase solubilization of corneal collagen fibers produced by corneal burns. Corneal ulcers usually occur after 2 to 3 weeks of ocular alkaline burn, which is due to the beginning of 2 weeks after injury, angle