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利用单相动作电位 (MAP)技术 ,研究在整体条件下四氢巴马汀 (THP)对家犬在体心脏MAP和有效不应期(ERP)的影响 ,从而探讨THP在整体条件下的抗心律失常机制。家犬 8只 ,体重 12 .5± 3.0 ( 10～ 15 )kg。同时记录家犬右室心尖部的MAP和体表Ⅱ导联心电图 (ECG) ,比较在窦性心律下用药前和用药后 10 ,2 0 ,30min的ERP、MAP复极 5 0 %时程 (MAPD5 0 )和复极 90 %时程 (MAPD90 )以及MAP振幅 (MAPA)的变化。结果 :用药后 10min ,各参数均无明显变化 (P >0 .0 5 ) ;用药 2 0min后 ,ERP、MAPD5 0 和MAPD90 与用药前相比 ,均明显延长 (分别为 139± 18msvs 12 4±18ms,12 6± 16msvs112± 15ms ,16 4± 2 5msvs 140± 16ms,P均 <0 .0 1) ,但用药前后ERP MAPD90 的比值无显著性变化 (P >0 .0 5 )。结论 :THP通过延长动作电位 2相和 3相时程 ,使ERP和MAPD90 平行延长 ,但不改变用药前后ERP MAPD90 比值 ,从而具有增加心肌电稳定性的作用 ,推测此是其具有抗室性心律失常的作用的可能机制
The single-phase action potential (MAP) technique was used to study the effect of tetrahydropalmatine (THP) on the body’s cardiac MAP and effective refractory period (ERP) in dogs under general conditions, so as to explore the effect of THP on global conditions Arrhythmia mechanism. Eight dogs, weighing 12.5 ± 3.0 (10 ~ 15) kg. At the same time, the MAP of right ventricular apex and electrocardiogram (ECG) of body surface Ⅱ were recorded. The ERPs of 10,2,0 and 30 min before and after administration of sinus rhythm were compared. MAPD5 0) and repolarization 90% of the time course (MAPD90) and MAP amplitude (MAPA) changes. RESULTS: After 10 minutes of treatment, there was no significant change in all parameters (P> 0.05). After 20 minutes of treatment, ERP, MAPD50 and MAPD90 were significantly prolonged (139 ± 18 ms vs 124 ± 18ms, 12 6 ± 16msvs112 ± 15ms, 16 4 ± 2 5msvs 140 ± 16ms, P <0.01). However, there was no significant difference in ERP MAPD90 before and after treatment (P> 0.05). CONCLUSIONS: THP prolongs the duration of 2-phase and 3-phase action potentials, prolonging the ERP and MAPD90 in parallel, but does not change the ratio of ERP MAPD90 before and after treatment, thereby increasing the electrical stability of the myocardium. This is presumed to be an anti-ventricular rhythm Possible mechanism of abnormal function