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目的介绍1例阿仑膦酸钠致老年女性骨质疏松患者癌胚抗原(CEA)反复增高,提醒临床医师用药时注意。方法给予1例老年女性骨质疏松患者口服阿仑膦酸钠,每次70 mg,每周1次。定期监测患者服药后血清CEA水平,并用Naranjo’s评估量表评价CEA升高与服用阿仑膦酸钠的关系。结果与结论患者服药后反复出现CEA持续性增高,停药后又逐渐下降。患者CEA升高与服用阿仑膦酸钠存在时间上的相关性,Naranjo’s评估该药物不良反应总得分为8分,说明CEA反复增高很可能与服用阿仑膦酸钠有关。
Objective To introduce the recurrence of carcinoembryonic antigen (CEA) in 1 case of osteoporosis induced by alendronate in elderly women, and to remind the clinician to pay attention to it. Methods One elderly osteoporosis female was given oral alendronate 70 mg once a week. Serum levels of CEA were regularly monitored in patients and the relationship between elevated CEA and alendronate sodium was assessed using Naranjo’s assessment scale. RESULTS AND CONCLUSION: CEA persistently increased in patients after medication and gradually decreased after stopping medication. Patients with elevated CEA and taking alendronate have time-related, Naranjo’s assessment of the adverse drug reaction score of 8 points, indicating that repeated CEA increase may be related to the use of alendronate.