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目的:探讨女性老年人高血压病肾气亏虚证、肝火上炎证与性激素相关调控因素的关联性,从而为研究老年人高血压病肾气亏虚证、肝火上炎证证候表现的病理生理基础提供依据。方法:根据高血压诊断与分级标准、中医辨证标准选择了女性高血压病肾气亏虚证、肝火上炎证患者各30例和健康老年女性30例,采用酶联免疫吸附法检测白介素-2(IL-2)、瘦素(Leptin)、肿瘤坏死因子(TNF-α)、促性腺激素释放激素(GnRH)和硫酸脱氢表雄酮(DHEA-S)的水平。结果:女性老年人高血压肾气亏虚证患者的性激素相关调控因素水平的异常变化与女性老年人高血压病肾气亏虚证的发病有关,预示血清白介素-2水平的异常变化可能是女性老年人高血压病肾气亏虚证形成的病理基础之一。
OBJECTIVE: To investigate the association between the syndrome of kidney-qi deficiency and the regulation of sex hormones in hypertension in the elderly, so as to study the syndrome manifestations of syndrome of kidney-qi deficiency, Provide the basis for the pathophysiology. Methods: According to the standard of diagnosis and grading of hypertension, 30 cases of female patients with renal insufficiency syndrome and 30 cases of healthy elderly women were selected according to TCM syndrome differentiation criteria. The levels of interleukin-2 IL-2, Leptin, TNF-α, GnRH and DHEA-S were measured. Results: Abnormal changes of sex hormone related regulatory factors in hypertensive and kidney-qi deficiency patients in the elderly were related to the pathogenesis of hypertensive renal insufficiency syndrome in the female elderly, indicating that the abnormal changes of the serum interleukin-2 levels might be female One of the pathological basis for the formation of hypertensive renal insufficiency syndrome.