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不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统感觉运动障碍性疾病,也是一种常见的睡眠疾病,影响患者的生活质量。其发病机制尚不十分明确,目前认为遗传因素、铁代谢异常、中枢多巴胺(DA)能系统功能异常及脊髓传导通路病变等与其发病相关。可根据有无原发疾病分为原发性RLS和继发性RLS。RLS在人群中的发病率为5%~10%,并且随年龄的增长有明显的上升趋势[1]。由于发现缺铁性贫血患者中RLS的发病率高达24%[2],近
Restless legs syndrome (RLS) is a common neurosensory movement disorder and is also a common sleep disorder that affects the quality of life of patients. Its pathogenesis is not yet fully understood. At present, genetic factors, abnormal iron metabolism, central dysfunction of dopamine (DA) system, and pathological changes of spinal cord conduction pathways are associated with its pathogenesis. According to whether the primary disease is divided into primary RLS and secondary RLS. The incidence of RLS in the population of 5% to 10%, and with age increased significantly upward trend [1]. As the incidence of RLS in patients with iron deficiency anemia was found to be as high as 24% [2],