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用左旋味唑(LMS)治疗50例慢性再生障碍性贫血,其中原发性22例,继发性28例。治疗方法,成人用量50mg 3次/天,每周服1～3天。结果。基本治愈10例(20％),缓解3例(6％),明显进步25例(50％),无效12例(24％),总显效率76％。对LMS治疗的作用机制及剂量与治疗关系,结合实验研究进行了分析。对治疗前病程及治疗情况与疗效的关系进行了讨论。LMS治疗再障副反应轻,口服方便,可以长期服用,随访5年余,个别患者连续服用40个月无不良反应。
50 cases of chronic aplastic anemia were treated with levamisole (LMS), including 22 cases of primary and 28 cases of secondary. Treatment, adult dosage 50mg 3 times / day, 1 to 3 days per week. result. Ten cases were cured (20%), 3 cases (6%) were alleviated, 25 cases (50%) were significantly improved, 12 cases (24%) were ineffective, and the total effective rate was 76%. The mechanism of LMS treatment and the relationship between dose and treatment, combined with experimental studies were analyzed. The relationship between pre-treatment course, treatment and curative effect was discussed. LMS treatment of aplastic anemia side effects, oral convenience, long-term use, more than 5 years follow-up, individual patients taking 40 consecutive months without adverse reactions.