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目的:探讨胸腺肽联合化疗对晚期胃肠道肿瘤患者细胞免疫功能的影响。方法:将80例晚期胃肠道肿瘤患者随机分为对照组和治疗组,对照组采用化疗治疗,治疗组在化疗基础上加用胸腺肽。另选25例体检健康者作为健康组。分别于治疗前及化疗两周期结束后10d检测外周血T淋巴细胞亚群及Th_1型细胞因子(IL-2)、Th_2型细胞因子(IL-10)。结果:晚期胃肠道肿瘤患者与健康组相比,T淋巴细胞亚群(CD_3~+,CD_4~+和CD_4~+/CD_8~+比值)及IL-2明显下降,CD_8~+及IL-10升高(P<0.05)。治疗后两组患者CD_4~+,CD_4~+/CD_8~+比值明显升高(P<0.05),治疗组变化更显著,与对照组比较差异显著(P<0.05)。治疗组患者IL-2下降(P<0.05),IL-10升高(P<0.05),对照组IL-2,IL-10化疗前后相比无统计学意义。试验组有效率高于对照组(P<0.05)。结论:晚期胃肠道肿瘤患者T淋巴细胞免疫功能低下,Th_2类细胞因子呈优势表达。胸腺肽联合化疗可加强杀灭肿瘤细胞,改善患者的细胞免疫功能。
Objective: To investigate the effect of thymosin combined with chemotherapy on cellular immune function in patients with advanced gastrointestinal cancer. Methods: Eighty patients with advanced gastrointestinal cancer were randomly divided into control group and treatment group. The control group was treated with chemotherapy. The treatment group was given thymosin on the basis of chemotherapy. Another 25 cases of physical examination as a healthy group. Peripheral blood T lymphocyte subsets and Thl type cytokines (IL-2) and Th2 type cytokines (IL-10) were detected at 10 days before and after the two cycles of chemotherapy. Results: The T lymphocyte subsets (CD_3 ~ +, CD_4 ~ + and CD_4 ~ + / CD_8 ~ + ratio) and IL-2 in patients with advanced gastrointestinal cancer were significantly lower than those in healthy group 10 increased (P <0.05). After treatment, the ratios of CD 4 +, CD 4 + / CD 8 + in both groups were significantly increased (P 0. 05). The changes in the treatment group were more significant than those in the control group (P 0. 05). IL-2 in the treatment group decreased (P <0.05), IL-10 increased (P <0.05), but there was no significant difference in the control group before and after the treatment of IL-2 and IL-10. The experimental group was more effective than the control group (P <0.05). Conclusion: The immune function of T lymphocytes in patients with advanced gastrointestinal cancer is poor, and Th2 type cytokines are predominantly expressed. Thymosin combined with chemotherapy can enhance the killing of tumor cells, improve the patient’s cellular immune function.