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目的:观察参松养心胶囊联合缬沙坦对高血压合并阵发性房颤(PAF)患者P波离散度(Pd)及血清炎症因子的影响。方法:选取河南中医药大学第三附属医院收治的高血压合并PAF患者94例,按照随机数字表法分为观察组和对照组,其中对照组给予缬沙坦治疗,观察组在对照组基础上联合参松养心胶囊治疗。观察两组P波最大时限(Pmax)、Pd和血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平。结果:治疗后两组Pd、Pmax显著低于治疗前,差异具有统计学意义(P<0.05),且观察组显著低于对照组,差异具有统计学意义(P<0.05);治疗后两组IL-6、TNF-α、hs-CRP水平显著低于治疗前,差异具有统计学意义(P<0.05),且观察组显著低于对照组,差异具有统计学意义(P<0.05)。结论:参松养心胶囊联合缬沙坦能够有效缩短高血压合并PAF患者Pd和Pmax,降低炎症因子水平。
Objective: To observe the effect of Shensong Yangxin Capsule combined with valsartan on P wave dispersion (Pd) and serum inflammatory factors in patients with hypertension and paroxysmal atrial fibrillation (PAF). Methods: Ninety-four patients with hypertension complicated with PAF admitted to the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine were divided into observation group and control group according to the random number table, in which the control group was treated with valsartan. The observation group was based on the control group Joint Shensong Yang Xin capsule treatment. Pmax, Pd, IL-6, TNF-α and hs-CRP in both groups were observed. Results: After treatment, the Pd and Pmax in both groups were significantly lower than those before treatment (P <0.05), and the difference between the two groups was statistically significant (P <0.05) The levels of IL-6, TNF-α and hs-CRP were significantly lower than those before treatment (P <0.05), and the difference between the two groups was statistically significant (P <0.05). Conclusion: Shensongyangxin capsule combined with valsartan can shorten the Pd and Pmax in patients with hypertension and PAF, and reduce the level of inflammatory cytokines.