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目的对比研究静脉注射胺碘酮与普罗帕酮转复阵发性心房颤动(房颤)的作用。方法72例房颤持续时间<48h的患者随机分为二组,胺碘酮组(n=36):胺碘酮150mg+生理盐水10ml,静注,10min注完;普罗帕酮组(n=36):普罗帕酮70mg+生理盐水10ml,静注,5～10min注完。观察30min若未转复可重复应用,最大累积量胺碘酮为450mg,普罗帕酮为210mg。结果转复率:胺碘酮组77.8％(28/36),普罗帕酮组75.0％(27/36),二组转复率比较差异无统计学意义(x2=0.0770,P>0.05)。转复时间:胺碘酮组(50.1±14.8)min,普罗帕酮组(39.6±13.7)min,二组比较差异有统计学意义(t=3.124,P<0.01)。结论胺碘酮和普罗帕酮对阵发性房颤均有较高的转复率,但转复时间普罗帕酮短于胺碘酮。
Objective To compare the effects of intravenous amiodarone and propafenone on paroxysmal atrial fibrillation (AF). Methods 72 patients with atrial fibrillation lasting less than 48h were randomly divided into two groups: amiodarone group (n = 36): amiodarone 150mg + saline 10ml, ): Propafenone 70mg + saline 10ml, intravenous injection, 5 ~ 10min Note finished. Observed 30min if not repeated application can be repeated, the maximum cumulative amount of amiodarone 450mg, propafenone 210mg. Results The recovery rate was 77.8% (28/36) in amiodarone group and 75.0% (27/36) in propafenone group. There was no significant difference in the recovery rate between the two groups (x2 = 0.0770, P> 0.05). The recovery time was statistically significant (t = 3.124, P <0.01) in amiodarone group (50.1 ± 14.8) min and propafenone group (39.6 ± 13.7) min. Conclusions Amiodarone and propafenone have higher conversion rate to paroxysmal atrial fibrillation, but propafenone is shorter than amiodarone during recovery time.