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帕金森病黑质多巴胺能神经元的死亡是发生了坏死还是凋亡,一直存有争议。目前越来越多的证据表明黑质多巴胺能神经元发生了凋亡,从而使其数量进行性减少,最后导致帕金森病,而神经元蛋白α-共核素可调节多巴胺能神经元的凋亡。
It has been controversial that the death of nigral dopaminergic neurons in Parkinson’s disease is necrosis or apoptosis. There is a growing body of evidence that apoptotic dopaminergic neurons in the substantia nigra cause progressive depletion of their numbers leading to Parkinson’s disease, whereas the neuronal α-synuclein modulates apoptosis in dopaminergic neurons Death.