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目的探讨老年食管癌放射治疗效果及其预后影响因素。方法选取2013年1—12月收治的老年食管癌患者120例作为研究对象,所有患者均接受放射治疗,回顾分析其临床基本资料及治疗效果,并对影响其治疗有效率的因素进行单因素和多因素回归分析,采用χ~2卡方检验对影响手术部位感染的单因素进行分析,并对单因素分析结果有统计学意义的因素进行Logistic多因素回顾分析,以P<0.05为差异有统计学意义。结果治疗有效率70.00%,1年生存率为90.83%,3年生存率为68.33%,中位生存时间为43.4个月;经单因素和多因素回归分析,确定肿瘤分期、放疗方式、放疗剂量等是影响食管癌患者治疗有效率的独立危险因素(均P<0.05)。结论老年食管癌的放射治疗效果及预后受肿瘤分期、放疗方式及剂量的影响,选择精确放疗,并在条件允许的情况下提高放疗剂量有利于患者生存时间的延长。
Objective To investigate the effect of radiotherapy on elderly esophageal cancer and its prognostic factors. Methods A total of 120 elderly patients with esophageal cancer who were admitted from January to December in 2013 were enrolled in this study. All the patients underwent radiotherapy. The basic clinical data and therapeutic effects were retrospectively analyzed. The factors influencing the therapeutic efficiency were evaluated by single factor and Multivariate regression analysis was used to analyze the single factor influencing surgical site infection by χ ~ 2 Chi-square test. Logistic regression analysis was used to analyze the factors that had statistical significance in the single factor analysis. P <0.05 was considered statistically significant Significance of learning. Results The effective rate of treatment was 70.00%, the 1-year survival rate was 90.83%, the 3-year survival rate was 68.33%, and the median survival time was 43.4 months. The single-factor and multi-factor regression analysis showed that the tumor stage, radiotherapy mode, Were independent risk factors influencing the treatment efficiency of patients with esophageal cancer (all P <0.05). Conclusion The radiotherapy effect and prognosis of esophageal cancer in elderly patients are affected by the staging of tumor, the mode of radiotherapy and the dosage. Precise radiotherapy is selected, and the dose of radiotherapy is increased if the conditions permit, which is in favor of prolonging the survival time of patients.