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很多年来临床上一直沿用外源性雌激素抑制产褥期泌乳,因有并发血栓栓塞危险而需寻求其它更理想的方法。本研究基于5羟色胺(Serotonin)有刺激生乳激素(PRL)分泌作用,因此试用强效的5羟色胺拮抗剂——Metergoline来抑制产褥期泌乳。本文报告身体健康而要求回奶的产妇30例,其中产后24小时内者20例;产后48小时内者3例和产后72小时内者7例。Metergoline用法:4毫克,3次/日,共5天。每天记录乳汁分泌量,乳房充盈和乳房疼痛二次。对产后24小时内的20例,在每天早晨用药后4小时内用双抗体放射免疫法测定血浆
For many years, the use of exogenous estrogen has been clinically used to inhibit puerperal lactation, due to the risk of concomitant thromboembolism and other more desirable methods. This study based on the serotonin (Serotonin) stimulates prolactin (PRL) secretion, so the trial of potent serotonin antagonist --Metergoline to inhibit puerperal lactation. This article reports 30 cases of maternal health requirements and return to milk, including 20 cases within 24 hours after delivery; 3 cases within 48 hours postpartum and 7 cases within 72 hours postpartum. Metergoline Usage: 4 mg, 3 times / day for 5 days. Daily recording of milk secretion, breast filling and breast pain twice. 20 cases within 24 hours postpartum, within 4 hours after each morning medication with double antibody radioimmunoassay of plasma