论文部分内容阅读
目的初步分析手传振动对广东打磨工人免疫球蛋白的影响。方法 2010~2012年广东省某3家企业从事打磨作业的179名工人和45名非打磨工人为研究对象,检测职业性手臂振动病病例组和对照组工人的免疫球蛋白G(Ig G)、免疫球蛋白A(Ig A)和免疫球蛋白M(Ig M),比较病例组与对照组间、不同患病严重程度间、住院治疗前后的免疫球蛋白含量的差异。结果与对照组、接振组比较,病例组Ig G降低,差异有统计学意义(P<0.05);手臂振动病中度患者Ig G、重度患者Ig M与对照组相比显示降低,差异有统计学意义(P<0.05),重度患者Ig A高于对照组,差异有统计学意义(P<0.05);振动病患者住院治疗后,Ig G仍持续降低、而Ig A和Ig M回升,差异均有统计学意义(P<0.05)。结论手传振动可影响工人的免疫系统,振动病患者Ig G、Ig A和Ig M水平降低,提示免疫作用可能与职业性手臂振动病发病机制相关。
Objective To analyze the influence of hand vibration on immunoglobulin of polish workers in Guangdong. Methods A total of 179 workers and 45 non-sanding workers from 3 enterprises in Guangdong Province from 2010 to 2012 were selected as research objects to detect Ig G, Immunoglobulin A (Ig A) and immunoglobulin M (Ig M). The differences of immunoglobulin levels between the case group and the control group before and after hospitalization were compared between the different severity of the disease. Results Compared with the control group and the vibration group, the Ig G in the case group was significantly lower (P <0.05); Ig G in moderate arm vibration patients and Ig M in severe cases were lower than those in the control group (P <0.05). The IgA in severe patients was higher than that in control group (P <0.05). After hospitalization, the Ig G level continued to decrease and Ig A and Ig M levels increased in sham-operated patients, The differences were statistically significant (P <0.05). Conclusion Hand-transmitted vibration can affect workers’ immune system. The levels of Ig G, Ig A and Ig M in vibration sickness patients decrease, suggesting that the immune function may be related to the pathogenesis of occupational arm vibration disease.