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目的采用犬实验性心肌缺血模型,观察宁心通痹胶囊抗心肌缺血的作用。方法 30只犬随机分成5组:模型对照组(注射生理盐水)、阳性对照组(20 mg·kg 1地奥心血康胶囊)、宁心通痹胶囊低中高剂量组。每组6只犬。结扎冠脉左前降支建立犬急性心肌缺血模型,观测心肌梗死范围、心电图、血流动力学及相关酶学指标等。结果宁心通痹胶囊在1.02,2.04 g·kg 1剂量下,对犬心肌缺血模型具有改善心电图S-T段偏移量,增加冠脉流量和心输出量,升高左心室收缩压作用,亦能缩小心肌梗死面积,改善心肌酶学等指标的异常。结论宁心通痹胶囊对犬心肌缺血具有明显的防治作用。
Objective To study the effect of Ningxintongbi Capsule on myocardial ischemia in dogs with experimental myocardial ischemia model. Methods Thirty dogs were randomly divided into five groups: model control group (saline injection), positive control group (20 mg · kg -1 Aoxinoxinkang capsule) and Ningxintongbi capsule low, medium and high dose group. 6 dogs in each group Ligation of coronary artery left anterior descending branch to establish canine model of acute myocardial ischemia, myocardial infarction range, ECG, hemodynamics and related enzymology indicators. Results Ningxin Tongbi Capsule can improve ST segment displacement, increase coronary flow and cardiac output, and increase left ventricular systolic pressure at 1.02,2.04 g · kg -1 in canine myocardial ischemia model Can reduce myocardial infarction area, improve myocardial enzymes and other indicators of abnormalities. Conclusion Ningxin Tongbi Capsule has significant preventive and therapeutic effects on myocardial ischemia in dogs.