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目的:研究慢性肾功能衰竭(CRF)患者氧自由基(OFR)对肾的损伤作用.方法:测定80例CRF患者和30例正常人血清脂质过氧化物(LPO)含量、超氧化物歧化酶(SOD)活性水平.结果:CRF患者血清LPO含量、总SOD、铜锌超氧化歧化酶(CUZN－SOD)、锰超氧化歧酶(MN－SOD)活性均较正常人明显增高(P＜0.01),且总SOD、CUZN－SOD、MN－SOD活性与血清肌酐呈显著正相关,与肾小球滤过率(GFR)呈显著负相关.结论:①CRF患者存在氧自由基的蓄积,脂质过氧化反应病理亢进和超氧化物歧化酶代偿性增高的病理改变;②血SOD活性可作为反映肾功能损害的可靠指标.“,”Objective:To study ou the change of OFR metabolism in CRF patients Methods:The serum concentration of lipid peroxide (LPO),and the activities of serum total superoxide dismutase (T SOD),including CuZn SOD、Mn SOD were measured in 80 cases of CRF patients and 30 healthy persons Results:The values of LPO、T SOD CuZn SOD、Mn SOD in CRF patients were increased signigicantly ( P 〈0 05～0 01);The serum concentration of creatinine was positively correlat...