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目的探讨胃黏膜癌前病变中p53和增殖细胞核抗原(PCNA)的表达及其临床意义。方法顺序选择病理检查为肠上皮化生、不典型增生、肠上皮化生不典型增生共存的患者各20例(分别为A、B和C组),另选20例正常者作为对照(D组)。免疫组化法检测其组织中p53和PCNA的表达。结果胃黏膜癌前病变中p53蛋白、PCNA表达水平均高于正常黏膜(P<0.01),表达水平从肠上皮化生、不典型增生到二者共存者呈递增趋势。结论p53和PCNA表达对评估胃黏膜癌前病变发展趋势有重要的临床价值,有助于早期发现胃癌。
Objective To investigate the expression of p53 and proliferating cell nuclear antigen (PCNA) in precancerous lesions of gastric mucosa and its clinical significance. Methods: The pathological examination was performed in 20 patients (group A, B and C respectively) with intestinal metaplasia, dysplasia and intestinal dysplasia, and 20 normal subjects as control group (D group) ). Immunohistochemistry was used to detect the expression of p53 and PCNA in the tissues. Results The expressions of p53 protein and PCNA in gastric mucosal precancerous lesions were significantly higher than those in normal mucosa (P <0.01). The expression levels of p53 and PCNA in gastric mucosal precancerous lesions increased from intestinal metaplasia and dysplasia to the coexistence of both. Conclusion The expressions of p53 and PCNA have important clinical value in assessing the development of precancerous lesions of gastric mucosa and are helpful for the early detection of gastric cancer.