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RU_(486)是一种甾体的抗孕激素制剂,它在受体水平拮抗孕酮和糖皮质激素的作用,但它与雄激素受体只有极弱的亲和性,对雌激素和盐皮质激素受体无亲和性。在几种动物种属已证明RU_(486)具有抗孕酮和致流产作用。首批临床试验已报道,给11例孕6～8周的妇女每天用200mg RU_(486)连用4天,其中9例导致流产。若于黄体期中期应用RU_(486)可在两天内引起月经出血。这提示RU_(486)是在靶器官水平拮抗孕酮的作用。虽然动物实验已证明RU_(486)只有抗孕酮作用而无孕素活性,但因动物实验的结果不能简单地用于人类,故本文在妇女观察了RU_(486)在内膜水平的抗孕酮作用,并试图探索RU_(486)是否有孕素活性。
RU 486 is a steroidal antiprogestin that antagonizes the effects of progesterone and glucocorticoid at the receptor level but has only a very weak affinity to the androgen receptor for estrogen and salt Corticosteroid receptor no affinity. RU_ (486) has been shown to have anti-progesterone and abortion effects in several animal species. The first clinical trials reported that 11 women aged 6-8 weeks were treated with 200 mg RU 486 per day for 4 days, 9 of which resulted in abortion. RU_ (486) in the mid-luteal phase can cause menstrual bleeding within two days. This suggests that RU_ (486) is antagonistic to progesterone at the target organ level. Although animal experiments have shown that RU 486 has only progesterone-free activity without progestin, the results of animal experiments can not simply be used in humans. Therefore, we examined the effect of RU_ (486) on endometrial level of anti-pregnancy Ketones and tried to explore if RU_ (486) had progestogenic activity.