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采用胶原酶诱导大鼠脑出血模型,以3H精氨酸转化测定法检测血肿周围缺血脑组织诱导型一氧化氮合酶(iNOS) 活性,并用电镜观察其病理改变,以探讨脑溢安颗粒( 简称脑溢安) 治疗脑出血的作用机制。结果显示:脑溢安明显抑制脑组织iNOS活性( P < 0 .01) ,改善脑组织水肿、细胞变性和坏死等神经病理改变。提示脑溢安对脑出血继发性脑缺血损伤具有保护作用,其机制可能与其抑制iNOS活性有关
The model of intracerebral hemorrhage was induced by collagenase, and the inducible nitric oxide synthase (iNOS) activity of ischemic brain tissue around the hematoma was detected by 3H-arginine conversion assay. The pathological changes were observed by electron microscope Particles (Erythromycin) for the treatment of intracerebral hemorrhage mechanism. Nao Yi An significantly inhibited iNOS activity in brain tissue (P <0.01), and improved neuropathological changes such as edema, cell degeneration and necrosis in brain tissue. Prompted Nao Yi An cerebral hemorrhage secondary cerebral ischemia injury has a protective effect, its mechanism may be related to its inhibition of iNOS activity