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本文报告一种新的易于制备的骨扫描剂:~(113m)In-三聚磷酸盐(~(113m)In-TPP),介绍其制备方法,在小鼠器官中的分布和进行人体骨扫描的初步结果。三聚磷酸钠(STPP)系将正磷酸二钠和正磷酸一钠以2:1M的比例混合,在540℃温度下熔融24小时制得。所得产品为微晶白色粉末,X线衍射研究证实为含六个水分子的三聚磷酸钠。向一系列按0.05ml分装的每毫升含100mgSTPP的水溶液加入递增数量的每毫升含3mgFeCl_3的0.05N HCl溶液,借此研究STPP对三价阳离子的络合能力。游离阳离子用比色法测定,因在分光光度比色计中加入0.1ml1%氰亚铁酸钾能生成铁的氰亚铁酸盐的蓝色络合物。结果证
This paper reports a new bone scavenger that is easy to prepare: ~ (113m) In-TPM (~ (113m) In-TPP), describes its preparation, distribution in mouse organs and bone scan The initial result. Sodium tripolyphosphate (STPP) was prepared by mixing disodium orthophosphate and monosodium orthophosphate in a ratio of 2: 1 M and melting at 540 ° C for 24 hours. The resulting product was a microcrystalline white powder which was confirmed by X-ray diffraction as sodium tripolyphosphate with six water molecules. To a series of 0.05 ml aliquots of an aqueous solution containing 100 mg STPP per ml in 0.05 ml HCl per ml of 3 mM FeCl 3, the complexing ability of STPP to the trivalent cation was investigated. The free cations were determined by colorimetry as the addition of 0.1 ml of 1% potassium ferrocyanide to a spectrophotometric colorimeter produced a blue complex of iron ferrocyanite. Results card