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Objective: To observe the effect of Ginkgo biloba extract injection (GB) in treating early diabetic nephropathy (DN). Methods: Sixty DN patients were divided into two groups, the treated group were treated by GB and West medicine, and the control group were given West medicine alone. The study lasted for 4 weeks. Fasting plasma glucose (FPG), blood pressure, 24 h urinary albumin excretion (UAE),endogenous creatinine clearance rate (Ccr), blood lipids and hemorheology indices were examined before and after the study. Results: Compared with the control group, UAE were significantly decreased (P＜0.01); Ccr, blood l ipids and hemorheology indices were all improved after treatment in the treated group (P＜0.05 or P＜0.01). But in FPG and blood pressure there was no significant change between the treated group and the control group (P＞0.05). Conclusion: GB is effective in treating early DN through decreasing urinary albumin excretion rate, regulating blood lipids, improving renal function and hemorheology.