论文部分内容阅读
目的通过观察二氧化硅致猪肺组织纤维化的变化,探讨无损伤矽肺大动物模型的制备及肺灌洗的疗效。方法采用非暴露法建立猪矽肺动物模型,将30只猪随机分成全氟化碳灌洗组、生理氯化钠灌洗组、对照组进行肺灌洗治疗,通过病理观察、灌洗液细胞学分析、X射线摄片观察肺内病变。结果2检验显示全氟化碳组、生理氯化钠组灌洗治疗的纤维化程度与对照组比较,差异无统计学意义(P>0.05);而通过观察建立起的猪矽肺病理模型,发现全氟化碳和生理氯化钠灌洗治疗组的纤维化程度明显低于对照组。结论采用非暴露法制备的矽肺模型和进行肺灌洗治疗,方法简便、安全,肺灌洗治疗有一定疗效。
Objective To observe the changes of lung tissue fibrosis induced by silicon dioxide in rats, and to study the preparation of non-injury silicosis animal model and the efficacy of lung lavage. Methods The porcine silicotic animal model was established by non-exposure method. Thirty pigs were randomly divided into perfluorocarbon-lavage group, physiological sodium chloride lavage group and control group for lung lavage. Pathological observation, lavage fluid cytology Analysis, X-ray observation of lung lesions. Results 2 test showed that there was no significant difference in the degree of fibrosis between perfusion of perfluorocarbon group and physiological sodium chloride group and the control group (P> 0.05). By observing the pathological model of pig silicosis, Found that perfluorocarbon and physiological sodium chloride lavage treatment group fibrosis was significantly lower than the control group. Conclusion The silicosis model prepared by non-exposure method and lung lavage therapy are simple, safe and effective in treating pulmonary lavage.