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青霉胺是含巯基化合物,原用作金属中毒的解毒剂,亦用于铜代谢障碍的肝豆状核变性。因其有巯基,可使属于巨球蛋白的类风湿因子裂解,故可用于类风湿关节炎。最近又进一步发现它能选择性地抑制某些免疫细胞,使IgG及IgM减少,显示它有免疫抑制作用。已用以治疗自身免疫性疾病包括类风湿关节炎、慢性活动性肝炎、硬皮病、口眼干燥关节炎综合征等,看来这方面的临床应用还会有发展。
Penicillamine is a sulfhydryl-containing compound that was originally used as an antidote to metal poisoning and is also used for hepatolenticular degeneration in disorders of copper metabolism. Because of its thiol, can belong to the macroglobulin rheumatoid factor lysis, it can be used for rheumatoid arthritis. It has recently been further found that it selectively inhibits certain immune cells, decreases IgG and IgM, and shows immunosuppressive effects. Has been used to treat autoimmune diseases including rheumatoid arthritis, chronic active hepatitis, scleroderma, dry mouth arthritis syndrome, it appears that there will be development in this area.