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[目的]探讨斑蝥酸钠维生素B6注射液联合紫杉醇与顺铂联合化疗方案(TP)化疗对晚期非小细胞肺癌(NSCLC)的疗效及对肿瘤标志物和血管新生指标的影响.[方法]本院收治的晚期NSCLC患者76例,随机分为两组,各38例.对照组患者接受TP化疗,观察组接受斑蝥酸钠维生素B6注射液联合TP化疗,均完成两疗程治疗.比较两组近期疗效及血清肿瘤标志物、血管新生指标含量的差异.[结果]治疗后,观察组患者的有效率(RR)、疾病控制率(DCR)均高于对照组(P<0.05),且血清中肿瘤标志物细胞角蛋白19片段(Cyfra21-1)、癌胚抗原(CEA)、糖类抗原125(CA125)含量及血管新生指标血管内皮生长因子(VEGF)、细胞血管生成素-2(Ang-2)、基质金属蛋白酶-9(MMP-9)的含量均低于对照组(P<0.05).[结论]斑蝥酸钠维生素B6注射液联合TP化疗可提升晚期NSCLC患者的治疗效果,降低肿瘤血管新生活性.“,”[Objective]ToinvestigatethetherapeuticeffectofsodiumcantharidatevitaminB6combined withpacLitaxeLandcispLatinchemotherapy(TP)onadvancednon-smaLLceLLLungcancer(NSCLC)anditsin-fLuenceontumormarkersandangiogenesis.[Methods]AtotaLof76casesofadvanced NSCLCpatientswas randomLydividedintotwogroup (n=38).PatientsinthecontroLgroupweretreatedwithTPchemotherapy onLywhiLethoseintheobservationgroupweretreatedwithsodiumcantharidincombinedwithTPchemothera-py.PatientsinbothgroupscompLeted2coursesoftreatment.Theshort-term efficacy,serum contentsof tumormarkersandangiogenesis markerswerecomparedbetweentwogroups.[ResuLts]After2coursesof treatment,theeffectiverate(RR)anddiseasecontroLrate(DCR)intheobservationgroupwerehigherthan thoseinthecontroLgroup (P<0.05)andtheserumtumormarkersCyfra21-1,(CEA),carbohydrateanti-gen125 (CA125)andangiogenesisindicatorsofvascuLarendotheLiaLgrowthfactor (VEGF),angiopoietin-2 (Ang-2),matrixmetaLLoproteinase-9wereLowerthanthecontroLgroup(P<0.05).[ConcLusion]Sodiumhy-aLuronatevitamin6combined with TPchemotherapycanimprovethetreatmenteffectinpatientswithad-vancedNSCLCandreduceangiogenesisactivity.