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乙氨芴酮(Tilorohe)是一种广谱的干扰素诱导剂,已逐渐被应用于治疗一些疾患。最近我们发现对治疗矽肺有一定疗效。为了探讨该药有无致突变作用,进行Ames试验,小鼠骨髓细胞染色体畸变及微核试验研究。实验材料与方法药物:用徐州第三制药厂生产的乙氨芴酮,其纯度为99.7％。一、Ames试验:根据Benedict报告单独使用鼠伤寒沙门氏菌TA1537菌系,共分五剂量组:0.5、1、2.5、5、7.5mg/皿,每剂量组分成不加S-9和加S-9的二人类,同时有水对照组及S-9对
Tilorohe is a broad-spectrum interferon inducer that has been gradually used to treat a number of conditions. Recently, we found that there is a certain effect on the treatment of silicosis. In order to investigate whether the drug has mutagenic effects, Ames test, chromosomal aberrations and micronucleus test of mouse bone marrow cells were performed. Experimental materials and methods Drugs: Ethyl fluorenone produced by Xuzhou No.3 Pharmaceutical Factory, with a purity of 99.7%. First, the Ames test: According to Benedict report alone Salmonella typhimurium TA1537 strain, is divided into five dose groups: 0.5,1,2.5,5,7.5 mg / dish, each dose component without S-9 plus S-9 Of the two human beings, with water control group and S-9 pairs