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脂质体是当在干燥脂膜层中加入水溶液后,由多层同轴心的脂质双层形成的显微泡囊。自从Bangham等首次发现后,多种脂质体被详细描述,多层脂质体或多层泡囊被广泛的用作抗肿瘤或抗微生物药剂的载体。这些多层泡囊由两个部分构成,一个是多层脂质构成的伸展的脂层相和一个由脂层间的空间构成的溶液腔。象大多数药物载体一样,脂质体被广泛用来改善有效药物的治疗指数,如阿霉素。研究发现药物毒性的大量降低与药物在靶器官分布的改变有关,脂质体优先被富含网状内皮系统细胞的器官吸收。在小鼠和人类中,脂质体被大量发现在肝、脾、肺和骨髓。由于脂质体独特的生物学、药理学特性,
Liposomes are microscopic vesicles formed from a plurality of concentric lipid bilayers when an aqueous solution is added to the dried lipid layer. Since the first discovery by Bangham et al., Various liposomes have been described in detail. Multilamellar liposomes or multilamellar vesicles are widely used as carriers for anti-tumor or antimicrobial agents. These multilamellar vesicles consist of two parts, one is a stretched lipid layer of multilamellar lipid and one solution chamber of space between the lipid layers. Like most drug carriers, liposomes are widely used to improve the therapeutic index of effective drugs, such as doxorubicin. The study found that a significant reduction in drug toxicity was associated with changes in drug target organ distribution, with liposomes being preferentially absorbed by organs rich in reticuloendothelial system cells. In mice and humans, liposomes are abundantly found in the liver, spleen, lung and bone marrow. Due to the unique biological and pharmacological properties of liposomes,