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目的 探讨免疫球蛋白在 MS病理过程中的作用机制与变化规律。方法 本文应用免疫组化法对 7例 MS患者的脑组织进行了 Ig A、Ig G、Ig M及 GFAP染色观察。结果 远隔病灶的白质区可见胞浆 Ig A、Ig G、Ig M及 GFAP阳性表达的星形胶质细胞 ;急性炎症坏死病灶内吞噬细胞胞浆 Ig A、Ig G、Ig M呈较强阳性表达 ;并且神经细胞 (主要为锥体细胞 ) Ig A、Ig G、Ig M也有较强的阳性表达。结论 MS是一种涉及中枢神经系统多种细胞的复杂免疫性疾病 ,可能与病毒感染有关。
Objective To investigate the mechanism and change of immunoglobulin in the pathogenesis of MS. Methods Immunohistochemistry was used to detect IgA, Ig G, Ig M and GFAP in brain tissue of 7 MS patients. Results Astrocytes with cytoplasmic Ig A, Ig G, Ig M and GFAP positive were seen in the white matter of distant lesions. The positive staining of Ig A, Ig G and Ig M in phagocytic cells in acute inflammatory necrosis lesions Expression; and nerve cells (mainly pyramidal cells) Ig A, Ig G, Ig M also have a strong positive expression. Conclusion MS is a complex immune disease involving a variety of central nervous system cells and may be related to viral infection.