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目的通过检测正常妊娠妇女的甲胎蛋白(AFP)含量,观察正常妊娠中AFP值变化及AFP值的随孕周变化的规律来了解正常妊娠AFP的发展过程。方法采用化学发光法对孕前期及6~40周怀孕妇女的AFP检测,并进行统计学处理。结果孕早期(6~14周)AFP浓度开始升高但上升缓慢,孕中期(15~20周)AFP值匀速成比例上升,直至32周左右达到峰值,孕晚期(33~40)周AFP浓度逐渐降低但保持一个较高水平。结论监测不同孕期的AFP值,用于孕早、中、晚期高危妊娠的筛查,以便尽早做出对于高危妊娠的判断和采取必要的措施。
Objective To detect the development of AFP in normal pregnancy by detecting the content of AFP in normal pregnant women and observing the changes of AFP value in normal pregnancy and the changes of AFP value with gestational weeks. Methods The chemiluminescence method was used to detect AFP in preconception and pregnant women from 6 to 40 weeks, and the results were statistically analyzed. Results The AFP concentration in the first trimester of pregnancy (6-14 weeks) began to increase but slowly increased. The AFP value at the second trimester (15-20 weeks) increased proportionally and reached a peak at around 32 weeks. The AFP concentration in the third trimester of pregnancy (33-40 weeks) Gradually lower but maintain a higher level. Conclusions AFP levels in different stages of pregnancy are monitored and used to screen for high-risk pregnancies in early, middle and late stages of pregnancy, so as to make early judgments on high-risk pregnancies and take the necessary measures.