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通过对丝状真菌G蛋白偶联受体(GPCR)的结构、分类以及功能方面进行综述,以期明确丝状真菌与其他模式生物GPCR之间的关系。基于已报道的模式生物及丝状真菌等不同生物中的GPCR,通过SMART保守结构域分析,以及利用Clustal X、MEGA等软件对上述GPCR进行遗传关系分析。明确丝状真菌典型GPCR具有七跨膜结构域,新型GPCR则含有PIPK、RGS等保守结构域,明确不同学者对于GPCR的分类情况,以及新型GPCR所具有的特殊功能,明确模式生物GPCR、丝状真菌GPCR分别各自聚类。丝状真菌中GPCR的数量较模式生物少,不同分类单元中真菌之间GPCR的数量也不尽相同,同时,丝状真菌GPCR除具有典型的七跨膜结构域外,还含有一些其他保守的结构域,上述研究为进一步开展其功能研究提供重要的理论基础。
The structural, classification and functional aspects of filamentous fungi G protein-coupled receptors (GPCRs) were reviewed in order to clarify the relationship between filamentous fungi and other model organism GPCRs. Based on the reported GPCRs in different organisms such as model organisms and filamentous fungi, the genetic relationship was analyzed by SMART conservative domain analysis and software such as Clustal X and MEGA. It is clear that typical GPCRs of filamentous fungi have a seven-transmembrane domain. The newer GPCRs contain conserved domains such as PIPK and RGS, clarify the classification of GPCRs by different scholars, and the special functions of novel GPCRs. Fungal GPCR clusters separately. The number of GPCRs in filamentous fungi is less than that in model organisms, and the number of GPCRs varies between fungi in different taxa. In addition, filamentous fungi GPCRs contain some other conserved structures in addition to the typical seven-transmembrane domain Domain, the above research provides an important theoretical basis for further carrying out its function research.