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自从Von Euler在30年代初期发现前列腺素(PG)后,由于它在组织内的含量极低,工作进展缓慢。直到60年代初期Bergstr(?)m搞清了PGE及F的化学结构,PG的化学、生化、生理和药理各方面的研究迅速开展,才逐渐认识它在体内的重要作用。1973年van Dorp等和Samuelsson等分别发现PG内过氧化物,使PG的研究出现了新的局面。这些内过氧化物(PGG及H)的生理作用比基本PG的作用强数百倍,它们是起PG作用的真正物质。1975年Samuelsson等发现Throm
Since the discovery of prostaglandin (PG) by Von Euler in the early 1930s, progress has been slow because of its extremely low levels in tissues. It was not until the early 1960s that Bergström clarified the chemical structure of PGE and F that the rapid development of PG chemistry, biochemistry, physiology and pharmacology was only gradually recognized in the body. In 1973, van Dorp et al. And Samuelsson et al. Respectively found that peroxides in PGs lead to a new situation in PG research. The physiological role of these endoperoxides (PGG and H) is hundreds of times stronger than that of basic PGs, and they are true substances that act as PGs. Samuelsson et al. Found Throm in 1975