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据报告,运动心电图阳性的严重多支冠脉疾病患者,作潘生丁(0.6mg/kg)应激超声心动图时,仅52%(11/21例)呈室壁运动异常。阳性率低是否由于潘生丁用量小,作者对此作了前瞻性研究。 55例可疑冠脉疾病,男41例,平均年龄55±9(38～73)岁。冠脉造影显示冠脉正常者15例,1、2和3支冠脉疾病(狭窄≥70%)分别为10、18和12例。静注潘生丁0.6mg/kg(5min),5min后再注射0.4mg/kg(5mim)。注射后30min作超声心动图。潘生丁剂量平均63±19(20～101)mg。这种1mg/kg潘生丁应激超声心动图检测冠脉疾病的敏感性40%,特异性93%;潘生丁应激心电图则分别为38%和80%。潘生丁应激超声心动图对1、2和3支冠脉疾病的敏感性分别为0%、50%和58%,潘生丁应激心电图则分别为0%、44%和58%。不良反应总发生率67%,严重者为低血压(7例)、窦性心动过
It has been reported that electrocardiogram positive patients with severe coronary artery disease, dipyridamole (0.6mg / kg) stress echocardiography, only 52% (11/21 cases) showed abnormal wall motion. Whether the low positive rate due to the small amount of dipyridamole, the authors made a prospective study. 55 cases of suspected coronary artery disease, 41 males, mean age 55 ± 9 (38 ~ 73) years old. Coronary angiography showed 15 normal coronary arteries, and 1, 2, and 3 coronary arteries (stenosis ≥70%) were 10, 18 and 12, respectively. Pancreatin 0.6 mg / kg intravenously (5min), 5min injection of 0.4mg / kg (5mim). 30min after injection for echocardiography. Diprandrine dose average 63 ± 19 (20 ~ 101) mg. This 1mg / kg dipyridamole stress echocardiography detection of coronary artery disease sensitivity 40%, specificity 93%; dipyridamole stress ECG were 38% and 80%. The sensitivity of dipyridamole stress echocardiography to 1, 2 and 3 coronary artery disease was 0%, 50% and 58%, respectively, and dipyridamole stress electrocardiogram was 0%, 44% and 58% respectively. The total incidence of adverse reactions 67%, severe cases of hypotension (7 cases), sinus tachycardia