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目的:探讨血糖对C反应蛋白(CRP)和可溶性细胞间黏附分子(sICAM1)的影响及其在腔隙性脑梗死(lacunarinfarction,LI)发病机制中的作用。方法:采用ELISA法对LI合并糖尿病和非合并糖尿病患者及正常人的血清CRP和sICAM1的表达进行检测。结果:糖尿病合并LI患者血清中sICAM1和CRP的水平高于非糖尿病合并LI患者,明显高于正常对照组;血糖与sICAM1、CRP呈正相关;LI灶的数目与患者血糖及sICAM1,CRP的水平呈正相关。结论:糖尿病加重了脑缺血炎症反应,其导致的sICAM1,CRP的高表达参与了LI微血管病变的损伤过程。
Objective: To investigate the effect of blood glucose on C-reactive protein (CRP) and soluble intercellular adhesion molecule (sICAM1) and its role in the pathogenesis of lacunarinfarction (LI). Methods: The serum levels of CRP and sICAM1 in LI patients with and without diabetes mellitus and normal subjects were detected by ELISA. Results: Serum levels of sICAM1 and CRP in diabetic patients with LI were significantly higher than those in non-diabetic patients with LI, which were significantly higher than those in controls. Blood glucose was positively correlated with sICAM1 and CRP. The number of LI foci was positively correlated with the level of blood glucose, sICAM1 and CRP Related. Conclusion: Diabetes mellitus aggravates the inflammatory reaction of cerebral ischemia. The high expression of sICAM1 and CRP is involved in the process of microvascular lesion.