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肝脏是非免疫球蛋白蛋白质的主要来源。现已有有力的证据说明肝脏是产生凝血因子Ⅰ(纤维蛋白原)、Ⅱ(凝血酶原)、Ⅴ(易变因子)、Ⅶ(稳定因子)、Ⅸ(血浆凝血活酶成分)和Ⅹ(Stuart-Prower因子)的场所,并认为Ⅺ(血浆凝血活酶前质)、Ⅻ(接触因子)及ⅩⅢ(纤维蛋白稳定因子)是在肝脏合成的。维生素K是合成凝血因子Ⅱ、Ⅶ、Ⅸ和Ⅹ的必需原料,这4个凝血因子称为凝血酶原复合物,也称为依赖维生素K凝血因子。肝脏病时这些凝血因子的水平可减低,而在肝外合成的一些凝血因子可能不减少。Deutsch统计一组各种肝脏病300例,85％以上的病人至少有1种以上凝血试验异常。患严重肝脏病的病人约有15％发生病理性出血。有些凝血试验反映肝脏的合成能力,可作为测定肝脏功能的一种方
The liver is the main source of non-immunoglobulin proteins. There is strong evidence that the liver is responsible for the production of coagulation factors (fibrinogen), prothrombin (II), V (volatile), Ⅶ (stabilizing factor), Ⅸ (plasma thromboplastin) and Ⅹ Stuart-Prower factor) and it is believed that XI (plasma prothrombin precursor), Limulus (contact factor) and XIII (fibrin stabilizing factor) are synthesized in the liver. Vitamin K is an essential raw material for the synthesis of clotting factors II, VII, IX and X. These four clotting factors are called prothrombin complexes and are also known as vitamin K-dependent clotting factors. The level of these clotting factors may be reduced in liver disease, while some of the extrahepatic coagulation factors may not decrease. Deutsch statistics a group of 300 cases of various liver diseases, more than 85% of patients have at least one or more clotting test abnormalities. About 15% of patients with severe liver disease have pathological bleeding. Some coagulation tests reflect the synthesis of the liver, liver function can be used as a party