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卵巢恶性肿瘤是常见的女性生殖系统三大恶性肿瘤之一,大多数起源于卵巢表面上皮。其中上皮性卵巢癌(epithelial ovarian carcinoma,EOC)是死亡率最高的妇科恶性肿瘤。上皮间充质转化(epithelial to mes-enchymal transition,EMT)是胚胎发育过程中的基本现象。近年研究发现,EMT不仅参与胚胎形成、组织的再生和修复,而且与上皮细胞性肿瘤的恶性进展也存在重要的联系。EMT的形成机制和进展的相关研究对于上皮性肿瘤的防治有重要意义,因此关于EMT在上皮性肿瘤形成和侵袭过程中的机制研究受到越来越多的关注。综述上皮性卵巢癌中EMT形成机制及其与卵巢上皮性肿瘤微环境和上皮性卵巢肿瘤相关信号通路的关系。
Ovarian cancer is one of the three major malignant tumors of the female reproductive system, most of which originate from the ovarian surface epithelium. Including epithelial ovarian carcinoma (epithelial ovarian carcinoma, EOC) is the highest mortality of gynecological malignancies. Epithelial-to-meschymal transition (EMT) is a fundamental phenomenon in embryonic development. Recent studies have found that EMT not only involved in embryogenesis, tissue regeneration and repair, but also with the malignant progress of epithelial tumor is also an important link. The research on the mechanism and progress of EMT is of great significance for the prevention and treatment of epithelial tumors. Therefore, more and more attention has been paid to the mechanism of EMT in the process of epithelial tumor formation and invasion. This review summarizes the mechanism of EMT formation in epithelial ovarian cancer and its relationship with epithelial ovarian tumor microenvironment and epithelial ovarian tumor-related signaling pathways.