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目的 :对两种不同的给药方案治疗下呼吸道感染性疾病进行药物经济学评价。方法 :选取 5 0例下呼吸道感染患者 ,随机分成两组 ,每组 2 5例 ,一组采用头孢呋辛静脉滴注给药 ;另一组采用头孢克罗 -头孢呋辛序贯治疗。并对两种方案进行药物经济学分析评价。结果 :两组在临床疗效、细菌清除率和不良反应发生率方面无显著性差异 (P >0 .0 5 )。但两组的医疗费用却有明显差别 (P <0 .0 1)。结论 :采用序贯疗法治疗下呼吸道细菌性感染 ,不但安全有效 ,而且医疗费用明显减少
OBJECTIVE: To evaluate the pharmacoeconomic evaluation of two different dosing regimens for the treatment of lower respiratory tract infections. Methods: Fifty patients with lower respiratory tract infection were selected and randomly divided into two groups (n = 25). One group was given cefuroxime intravenously. The other group was treated with cefaclor and cefuroxime sequentially. And the two programs for drug economics analysis and evaluation. Results: There was no significant difference between the two groups in clinical efficacy, bacterial clearance rate and incidence of adverse reactions (P> 0.05). However, there was a significant difference in medical costs between the two groups (P <0.01). Conclusion: Sequential treatment of bacterial infections of the lower respiratory tract is not only safe and effective, but also significantly reduces medical costs