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OBJECTIVE Midkine (MK),a new member of the heparin-binding growth factor family,was found recently to have a highexpression level in many carcinoma specimens,including thoseof the esophagus,gall bladder,pancreas,colorectum,breast andlung.Estrogen receptor beta (ER-β),a recently cloned estrogenreceptor subtype,was also found to be highly expressed in lungtumor tissue,in contrast to a lower level of expression in normallung tissue.However,few relevant studies on these proteins havebeen published.The aims of our study were to investigate theexpression of midkine and ER-β proteins in non-small cell lungcancer (NSCLC) and to examine the relationship between theirexpression and the clinicopathologic data as well as to analyse thecorrelation of their expression in NSCLC.METHODS By immunohistochemistry,MK and ER-β were ex-amined in 24 surgically resected cases of NSCLC with their corre-sponding paraneoplastic and normal lung tissues.RESULTS MK and ER-β were overexpressed in NSCLC.Thelevels of MK and ER-β expression in NSCLC were found to be sig-nificantly negatively correlated with the pathological classification(P=0.042 and 0.021,respectively),and their expression decreasedwith a raise in the classification.Spearman’s correlation analysisshowed that the correlation of their expression in NSCLC wasstrong (correlation coefficient[r_s]= 0.535,P=0.007<0.01).CONCLUSION The expression levels of MK and ER-β to someextent reflect the malignant degree of NSCLC,and their combineddetection may be of great value in early diagnosis,treatments ofpatients with NSCLC and can predict the prognoses.
OBJECTIVE Midkine (MK), a new member of the heparin-binding growth factor family, was found recently to have a highexpression level in many carcinoma specimens, including those of the esophagus, gall bladder, pancreas, colorectum, breast and lung. Estrogen receptor beta ( ER-β), a recently cloned estrogen receptor subtype, was also found to be highly expressed in lung tumor tissue, in contrast to a lower level of expression in normal lung tissue. Despite, few relevant studies on these proteins havebeen published. Aims were to investigate the expression of midkine and ER-β proteins in non-small cell lung cancer (NSCLC) and to examine the relationship between theirexpression and the clinicopathologic data as well as to analyze thecorrelation of their expression in NSCLC. METHODS By immunohistochemistry, MK and ER -β were ex-amined in 24 surgically resected cases of NSCLC with their corre-sponding paraneoplastic and normal lung tissues .RESULTS MK and ER-β were overexpressed in NSCLC.The levels of MK and ER-β expression in NSCLC were found to be sig-nificantly negatively correlated with the pathological classification (P = 0.042 and 0.021, respectively), and their expression decreased with a raise in the classification. Spearman’s correlation analysis showed that the correlation of their CONCLUSION The expression levels of MK and ER-β to someextent reflect the malignant degree of NSCLC, and their combined detection may be of great value in early diagnosis. , treatments of patients with NSCLC and can predict the prognoses.