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目的:观察丹参注射液对胃癌术后患者血液高凝状态的影响。方法:选择行胃癌根治术后患者60例,随机分为对照组(C组)和丹参组(D组),每组30例。对照组采用常规化疗;丹参组在常规化疗的基础上,加用丹参注射液治疗。于化疗前后取外周血检测患者凝血功能,采用血栓弹力描记仪分析凝血状态的变化,彩色多普勒超声诊断深静脉血栓形成(deep venous thrombosis,DVT)。结果:与化疗前比较,D组患者化疗后的凝血功能明显改善(P<0.05),凝血指数明显下降(P<0.05),差异有统计学意义。与C组化疗后比较,D组化疗后的凝血功能和凝血指数明显改善(P<0.05),差异有统计学意义。化疗后,D组有3例(10%)患者发生DVT,而C组有12例(40%)患者发生DVT(P<0.05)。结论:丹参注射液能够改善胃癌术后患者血液高凝状态并减少DVT的发生。
Objective: To observe the effect of Danshen injection on blood hypercoagulability in patients with gastric cancer. Methods: Sixty patients undergoing radical gastrectomy were randomly divided into control group (C group) and Salvia miltiorrhiza group (D group), 30 cases in each group. The control group was treated with conventional chemotherapy; the Danshen group was treated with Danshen injection on the basis of conventional chemotherapy. Coagulation function was measured in peripheral blood before and after chemotherapy, blood coagulation status was analyzed by thromboelastography, and color Doppler ultrasonography was used to diagnose deep venous thrombosis (DVT). Results: Compared with before chemotherapy, the coagulation function of group D was significantly improved after chemotherapy (P<0.05), and the clotting index was significantly decreased (P<0.05). The difference was statistically significant. Compared with group C after chemotherapy, the coagulation function and coagulation index of group D after chemotherapy were significantly improved (P<0.05), and the difference was statistically significant. After chemotherapy, DVT occurred in 3 patients (10%) in group D, and DVT occurred in 12 patients (40%) in group C (P<0.05). Conclusion: Danshen injection can improve the blood hypercoagulability and reduce the occurrence of DVT in patients with gastric cancer.