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目的：观察经诱导后动物产生的抗胃癌生物活性肽对荷瘤鼠瘤细胞及脾脏细胞超微结构的影响。方法：取４周龄ＢＡＬＢ／Ｌ裸鼠随机分两组均注射ＢＧＣ—８２３细胞，３ｄ后实验组腋皮下注射抗胃癌活性肽，对照组注射生理盐水，３０ｄ后处死动物取瘤体称重，瘤、脾组织按常规法制备电镜样品，Ｈ—７００电镜观察。结果：对照组瘤体重，瘤细胞为典型的癌细胞特征，脾细胞超微结构受损。实验组瘤体重量减轻，瘤细胞向正常细胞分化并伴有癌细胞凋亡。脾细胞超微结构接近正常。结论：抗胃癌生物活性肽有抑制肿瘤增长，诱导瘤细胞向正常细胞分化及凋亡的功能。同时对机体免疫器官有调节作用。
OBJECTIVE: To observe the effect of anti-cancer biologically active peptides produced by animals on the ultrastructure of tumor cells and spleen cells in tumor-bearing mice. METHODS: Four-week-old BALB/L nude mice were randomly divided into two groups and injected with BGC-823 cells. Three days later, the experimental group received subcutaneous injections of anti-gastric cancer active peptides. The control group received normal saline injection. After 30 days, the animals were sacrificed and the tumors were weighed. Tumors and spleen were prepared by electron microscopy according to conventional methods and observed by H-700 electron microscope. RESULTS: In the tumor weight of the control group, the tumor cells were typical cancer cell characteristics, and the ultrastructure of spleen cells was impaired. The weight of the tumor in the experimental group was reduced, and the tumor cells differentiated into normal cells and accompanied by apoptosis of the cancer cells. The ultrastructure of splenocytes is close to normal. Conclusion: Anti-gastric cancer bioactive peptides can inhibit tumor growth and induce the differentiation and apoptosis of tumor cells into normal cells. At the same time, it regulates the immune organs of the body.