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随着糖尿病发病率的逐年升高,很好地控制糖尿病患者的血糖,对预防和延缓糖尿病并发症,尤其是微血管并发症有着重要的意义。糖尿病眼底病变和糖尿病肾病是较常见的微血管病变,也是糖尿病患者致死和致残的主要原因,而人胰岛素很好地控制病情发展。 胰岛素是胰岛素依赖型糖尿病(IDDM)患者所必需,否则将出现急性糖代谢紊乱如酮症酸中毒昏迷等,生存每时每刻受到危胁,非胰岛素依赖型糖尿病(NIDDM)患者在饮食、运动、口服降糖药物治疗均不能使血糖控制在理想水平或出现严重并发症时,也应加用或改用胰岛素治疗。既往我们临床上使用的多为动物胰岛素,与人胰岛素氨基酸排列上有一定程度差异,应用于人具有免疫原性,长期应用后体内产生抗胰岛素抗体,致使胰岛素的使用剂量逐渐增大,甚至失效,也是导致高血糖与低血糖交替出现的原因之一。人胰岛素的免疫原性和抗原性明显低于动物胰岛
With the increasing incidence of diabetes, good control of blood glucose in diabetic patients, prevention and delay of diabetes complications, especially microvascular complications is of great significance. Diabetic retinopathy and diabetic nephropathy are the more common microvascular diseases and are also the leading cause of death and disability in people with diabetes, and human insulin well controls the progression of the disease. Insulin is essential for patients with insulin-dependent diabetes mellitus (IDDM), otherwise acute glucose metabolism disorders such as ketoacidosis coma will occur, survival is threatened at all times and non-insulin dependent diabetes mellitus (NIDDM) , Oral hypoglycemic drug therapy can not make the blood sugar control in the ideal level or serious complications, should also be added or changed to insulin therapy. In the past, most of our clinical use of animal insulin, and human insulin amino acid arrangement has a certain degree of difference, applied to human immunogenicity, long-term use of anti-insulin antibodies in vivo, resulting in the dose of insulin gradually increased, or even failure , Is also one of the reasons leading to the alternation of hyperglycemia and hypoglycemia. Human insulin is significantly less immunogenic and antigenic than animal islets