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目的：探讨免疫抑制药物对成人型多囊肾病（ Ａ Ｐ Ｋ Ｄ）的治疗作用及其作用机制。方法：回顾总结２４ 例 Ａ Ｐ Ｋ Ｄ患者肾移植并免疫抑制治疗［均为常规的环孢素 Ａ（ Ｃｓ Ａ）、硫唑嘌呤（ Ａｚａ）、泼尼松（ Ｐｒｅｄ）三联方案］前后情况，对比观察的指标是腰部胀痛、肉眼血尿、高血压、多囊肾大小。结果：移植术后腰部胀痛症状改善最为明显； 术前频发肉眼血尿者为８３．３％ ，术后减为１２．５％ ，相差非常显著（ Ｐ＜ ０．０１）；高血压在术后 １ 个月内改善不明显，而在术后１ 年时改善非常明显（ Ｐ＜ ０．０１）；多囊肾 Ｂ超测定值，术前与术后各期相比， 大小无显著差异，呈现“稳定”状态。结论： Ａ Ｐ Ｋ Ｄ 患者肾移植术后腰部胀痛、血尿、高血压等症状的改善可归因于免疫抑制药物的治疗作用。推测其作用机制，可能 Ａ Ｐ Ｋ Ｄ属基因决定基础上的免疫性疾病，或免疫因素在其病程中起重要作用，因此免疫抑制药物可能对 Ａ Ｐ Ｋ Ｄ 具有治疗作用。
Objective: To investigate the therapeutic effect of immunosuppressive drugs on adult polycystic kidney disease (ADPK) and its mechanism. Methods: A retrospective review of 24 patients with A P K D before and after renal transplantation and immunosuppressive therapy [both conventional Cs A, Aza and Pred triple regimens] Comparative observation of indicators of waist pain, gross hematuria, hypertension, polycystic kidney size. Results: The most obvious symptom of lumbar pain was relieved after the operation. The preoperative frequency of gross hematuria was 83.3%, and the difference was 12.5% after operation. The difference was significant (P <0.01) After 1 month, the improvement was not obvious (P <0.01). The measured value of polycystic kidney B-ultrasound, there was no significant difference between the preoperative and postoperative levels, Showing a “stable” state. CONCLUSIONS: The improvement of symptoms such as lumbar pain, hematuria and hypertension after renal transplantation in patients with AKD can be attributed to the therapeutic effect of immunosuppressive drugs. Presumably its mechanism of action may be that APKD is a genetic determinant based on the immune disease, or immune factors play an important role in its course, so immunosuppressive drugs may have a therapeutic effect on APK.