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目的 :探讨血清层粘连蛋白 (LN)、Ⅳ型胶原 (Ⅳ·C)与系统性红斑狼疮 (SLE)的关系。方法 :应用ELISA法对2 3例活动期、11例稳定期SLE患者及 2 0例正常人血清LN和Ⅳ·C水平进行了检测。结果 :活动期SLE患者血清LN及Ⅳ·C水平明显高于稳定期患者及正常人 (P <0 .0 1) ,稳定期SLE患者与正常人比较无明显差异 (P >0 .0 5 )。结论 :血清LN、Ⅳ·C水平检测可作为SLE是否活动及疗效和预后观察的参考指标
Objective: To investigate the relationship between serum laminin (LN), type Ⅳ collagen (Ⅳ · C) and systemic lupus erythematosus (SLE). Methods: Serum levels of LN and Ⅳ · C were detected in 23 SLE patients, 11 stable SLE patients and 20 normal controls by ELISA. Results: The levels of serum LN and Ⅳ · C in active SLE patients were significantly higher than those in stable patients and normal subjects (P <0.01). There was no significant difference between stable SLE patients and normal controls (P> 0.05) . Conclusion: The detection of serum LN, Ⅳ · C levels can be used as a reference for SLE activity and efficacy and prognosis