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目的:观察扶正清肝汤治疗慢性乙型肝炎的临床疗效及不良反应。方法:将124例乙型肝炎患者随机分为对照组和治疗组各62例,疗程为1年。对照组给予恩替卡韦治疗,治疗组在对照组的基础上给予扶正清肝汤治疗。每月随访记录症状、体征、不良反应,治疗前及治疗后每3个月记录血清病毒指标乙肝表面抗原(HBs Ag)、乙肝病毒e抗原(HBe Ag)、乙肝病毒e抗体(HBe Ab)、乙肝病毒(HBV-DNA、血常规、肝肾功能,随访1年后治愈率。不良反应以症状为主。结果:治疗后治疗组HBe Ag阴转率、HBe Ab阳转率、HBV-DNA阴转率、ALT复常率、治愈率均明显高于对照组,差异具有统计学意义(P<0.05);观察组1例(1.61%)和对照组7例(11.29%),出现恶心、头晕、腹部不适等,观察组不良反应总出现率明显低于对照组,差异具有统计学意义(P<0.05)。结论:扶正清肝汤联合恩替卡韦可明显改善症状,提高治愈率,不良反应小。
Objective: To observe the clinical effect and adverse reaction of Fuzheng Qinggan decoction in treating chronic hepatitis B Methods: 124 patients with hepatitis B were randomly divided into control group and treatment group of 62 cases, the course of treatment was 1 year. The control group was treated with entecavir. The treatment group was given Fuzheng Qinggan Decoction on the basis of the control group. The symptoms, signs and adverse reactions were recorded on monthly follow-up. Serum viral markers HBsAg, HBeAg, HBeAb were recorded before treatment and every 3 months after treatment. Hepatitis B virus (HBV-DNA, blood, liver and kidney function, follow-up 1 year after the cure rate, the main adverse reactions with symptoms.Results: After treatment, the HBe Ag negative conversion rate, HBe Ab positive conversion rate, HBV- (P <0.05). One case (1.61%) in the observation group and 7 cases (11.29%) in the control group showed nausea and dizziness, the rate of recovery of ALT and the cure rate were significantly higher than those of the control group , Abdominal discomfort, the total incidence of adverse reactions in the observation group was significantly lower than the control group, the difference was statistically significant (P0.05) .Conclusion: Fuzheng Qinggan decoction combined with entecavir can significantly improve the symptoms, improve the cure rate, adverse reactions.